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Ullal, Sheetal
- Evaluation of Hypolipidemic Effects of Lyciumbarbarum (goji Berry) in a Murine Model
Authors
Source
Journal of Natural Remedies, Vol 13, No 1 (2013), Pagination: 4-8Abstract
Lycium barbarum L. Solanaceae a traditional medicinal plant of China has been accorded a very high safety value. It has been known to possess various beneficial effects like reduction of blood glucose and serum lipids in alloxan-induced diabetes models, anti-ageing, immuno-modulating, anti-cancer, anti-fatigue, and male fertility-facilitatory actions. The present study is an attempt to explore the hypolipidemic effects of powdered L. barbarum in high fat diet-induced model of hyperlipidemia. Powdered L. barbarum fruit extract (250mg/kg and 500mg/kg) was administered to Wistar albino rats fed on a cholesterol-rich high-fat diet for 45 days. The effects were compared with the standard drug atorvastatin (10 mg/kg/day, oral). After 30 days of treatment, the lipid profile of the blood samples of the experimental rodents was evaluated.The data presented as meanĀ±SEM were analysed using one-way ANOVA followed by Tukey's post hoc test. P<0.05 was considered as statistically significant. In the present study, L. barbarum powdered extract showed a significant reducti on in the total cholesterol, triglycerides and very low density lipoprotein-cholesterol levels at both the doses employed (p<0.05). However, reduction in low density lipoprotein-cholesterol levels was significant (p<0.05) only at the dose of 500 mg/kg when compared to the standard drug group. The increase in high-density lipoprotein levels was significant only at 250 mg/kg. The data thus suggests the positive anti -hyperlipidemic activity of L. barbarum in high fat diet-induced hyperlipidemia in rats.Keywords
Goji berry, Hypolipidemic activity, High-fat diet, Lyciumbarbarum- Seasonal Variation and Malaria in Endemic Mangalore City in South India
Authors
1 Tutor, Department of Pharmacology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, IN
2 Professor and Head, Department of Community Medicine, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka
3 Associate Professor, Department of Pharmacology Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, IN
4 Associate Professor, Department of Microbiology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, IN
5 Professor and Head, Department of Emergency Medicine, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, IN
6 Professor and Head, Department of Pathology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, IN
Source
Indian Journal of Public Health Research & Development, Vol 11, No 1 (2020), Pagination: 521-525Abstract
Background: In the year 2017 India has contributed to 4% of global malaria cases and Mangalore is endemic to malaria. Malaria transmission also depends on the season of the year, i.e. the wet or dry season. Regardless of huge endemicity and massive health burden, at present limited data has been documented on malaria prevalence and factors contributing to prevalence of malaria and its association with seasonal factors in Mangalore region.
Objective: To study the seasonal variations in malaria burden and species prevalence in Mangalore.
Settings and Design: This is a cross-sectional study conducted at District hospital.
Methods and Material: Patients with microscopically confirmed malaria attending the District hospital were included in the study. Demographic details were collected from participants.
Statistical Analysis Used: Descriptive statistics.
Results: In this region malaria is present all around the year and Plasmodium vivax is more predominant than Plasmodium falciparum. The number of cases peaks during the rainy season suggesting that high rains provide an ideal environment for malaria transmission.
Conclusions: A complex relationship exists between rainfall, temperature, occupation and malaria. Implementing malaria elimination interventions such as preventing water clogging, cleaning the water bodies and increasing awareness for use of prevention practices might help in reducing malaria burden in Mangalore.